Melekess is the second largest city in Iskirra. It is known for being a historic town and a center of political and social discourse.
A sect of transhumanist magicians existed in Melekess. These people wanted to use a combination of science and magic (which they considered synonymous with technology) to improve humanity. When Eugene Benedict encountered them, he initially agreed with their goals, but after seeing the results of their experimentation he was frightened and distanced himself from them.